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Medical Journal Updates
Neuropathological findings in autism.
http://brain.oxfordjournals.org/cgi/content/full/127/12/2572
Differences in the brain’s hippocampus and amygdala in autism.
http://ajp.psychiatryonline.org/cgi/content/full/161/11/2038
Brain abnormalities in children with autism.
http://brain.oxfordjournals.org/cgi/content/full/126/5/1182
Supplementation therapy for autism.
http://www.asha.ucf.edu/Nye&Brice2002.PDF
Secretin trial in autism.
http://www.theannals.com/cgi/content/abstract/36/2/305
The following are available in various formats. Some are available on the Internet with no user
fee; some are available with subscriber fees; and some must be accessed from the original
journal.
Autism Studies and Articles:
Aschner, M., et al. The Neuropathogenesis of Mercury Toxicity. Molecular Psychiatry.
Supp. 2. 2002; 7:S40-S41.
Baron-Cohan, S., et al. The Amygdala Theory of Autism. Neurosci Biobehav. 2000; rev. 24:
355
Baron-Cohen, S., et al. Autism Occurs More Often in Families of Physicists, Engineers, and
Mathematicians. Autism. 1995; 2:296-301
Bernard, S., et al. Autism: A Novel Form of Mercury Poisoning. Medical Hypotheses. 2001;
56:462-471.Bernard, S., et al. The Role of Mercury in the Pathogenesis of Autism.
Molecular Psychiatry. 2002; 7:S42-S43.
Bradstreet, J., et al. A Case-Control Study of Mercury Burden in Children with Autistic
Spectrum Disorders. Journal of American Physicians and Surgeons. 2003; 8(3):76-79.
Bradstreet, J., et al. A Case-Control Study of Mercury Burden in Children with Autistic
Spectrum Disorders. Journal of American Physicians and Surgeons. 2003; 8(3):76-79.
Chauhan, A., et al. Oxidative Stress in Autism: Increased Lipid Peroxidation and Reduced
Serum: Levels of Ceruloplasmin and Transferrin – the Antioxidant Proteins. Life Sci. Oct.,
2004; 8:75(21): 2539-2549.
Deplancke, B., et al. Redox Control of the Transsulfuration and Glutathione Biosynthesis
Pathways. Curr Opin Clin Nutr Metab Care. 2002; 5:85-92
El-Dahr, Jane M., M.D. Thimerosal Containing Vaccines and Neurodevelopmental
Outcomes. National Academy of Sciences, Institute of Medicine, Immunization Safety
Review Committee. July 16, 2001.
Finkelstein, J. D. Methionine Metabolism in Mammals. J Nutr Biochem. 1990; 1:228-237.
Finkelstein, J.D. The Metabolism of Homocysteine: Pathways and Regulation. Eur J
Pediatr. 1998; 157:S40-S44
Geier, D.A., et al. A Comparative Evaluation of the Affects of MMR Immunization and
Mercury Doses from Thimerosal-Containing Childhood Vaccines on the Population
Prevalence of Autism. Med Sci Monit. 2004; 10:P133-P139.
Gordon, C. T., et al. A Double-Blind Comparison of Clomipramine, Desipramine, and
Placebo in the Treatment of Autistic Disorder. Archives of General Psychiatry. 1993; 50:441-
447.
Hashimoto, T., et al. Development of the Brainstem and Cerebellum in Autistic Patients. J
Autism Dev Disord. 1995; 25:1-18.
Holmes, A., et al. Open Trial of Chelation of Children with Autism. Presentation at the
International Meeting for Autism Research. 2002.
Horvath, K., et al. Gastrointestinal Abnormalities in Children with Autistic Disorder. J
Pediatr. 1999; 135:599-563.
James, S. J., et al. Impaired Methylation Capacity and Increased Oxidative Stress in
Children with Autism. Am J Clin Nutr.
James, S. J., et al. Metabolic Biomarkers of Increased Oxidative Stress and Impaired
Methylation Capacity in Children with Autism. Am J Clin Nutr. 2004; 80:1611-1617.
Madsen, K. M., et al. Thimerosal and the Occurrence of Autism: Negative Ecological
Evidence from Danish Population-Based Data. Pediatrics. 2003; 112:604-606.
Megson, M. N. Is Autism a G-Alpha Protein Defect Reversible with Natural Vitamin A? Med
Hypotheses. 2000; 54:979-983
Pangborn, J. B., Baker, S. M. Biomedical Assessment Options for Children with Autism and
Related Problems. San Diego, CA: Autism Research Institute. 2001
Rapin, I., et al. Neurobiology of Autism. Ann Neurol. 1998; 43:7-14.
Rimland, B. Dimethylglycine (DMG), a Nontoxic Metabolite, and Autism. Autism Research
Review International. 1990; 4:2.
Rimland, B. Infantile Autism: the Syndrome and its Implications for a Neural Theory of
Behavior. New York: Appleton Century Crofts. 1964.
Schulz, J. B., et al. Glutathione, Oxidative Stress and Neurodegeneration. Eur J Biochem.
2000; 267:4904-4911
Shattock, P., et al. Role of Neuropeptides in Autism and their Relationships with Classical
Neurotransmitters. Brain Dysfunct. 1990; 3:328-345.
Vojdani, A., et al. Infections, Toxic Chemicals and Dietary Peptides Binding to Lymphocyte
Receptors and Tissue Enzymes are Major Instigators of Autoimmunity in Autism. Intl J
Immunopath and Phar. 2003; 16:189.199.
Wakefield, A. J., et al. Illeal-Lymphoid Nodular Hyperplasia, Non-specific Colitis, and
Pervasive Developmental Disorder in Children. Lancet. Feb. 28, 1998; 351: 9103.
Whiteley, P., et al. A Gluten Free Diet as Intervention for Autism and Associated Disorders
Preliminary Findings. Autism: Intl J Res Pract. 1999; 3:45-65.
Zuddas, A., et al. Clinical Effects of Clozapine on Autistic Disorder (letter). American
Journal of Psychiatry. 153:1996; 738.
ADHD Studies and Articles
August, G., et al. Comorbidity of ADHD and Reading Disability Among Clinic-Referred
Children. Journal of Abnormal Child Psychology. 8(1):29-45.
Barone, S., et al. Vulnerable Processes of Nervous System Development: A Review of
Markers and Nervous Neurotoxicology. 2000; 21:15-36.
Bateman, B., et al. The Effects of a Double-Blind, Placebo Controlled, Artificial Food
Colorings and Benzoate Preservative Challenge on Hyperactivity in a General Population of
Preschool Children. Arch Dis Child. Jun. 2004.
Biederman, J., et al. Pharmacotherapy of Attention Deficit Hyperactivity Disorder Reduces
Risk for Substance Use Disorder. Pediatrics. 104(2):20.
Bornstein, R., et al. Plasma Amino Acids in Attention Deficit Disorder. Psychiatry
Research. 1990; 33(3):301-306.
Haber, J. Medication in Hyperactive Children. Pediatrics. 80(5):758-760.
Hagberg, H., et al. Effect of Inflammation on Central Nervous System Development and
Vulnerability. Current Opinion in Neurology. 2005; 18:117-123.
Hallowell, E. M., et al. Driven to Distraction. New York: Pantheon. 1994; 282.
Hauser, P., et al. Attention Deficit Hyperactivity Disorder in People with Generalized
Resistant Thyroid Hormone. New England Journal of Medicine. 1993; 328(14):997-1003.
Hunt, R., et al. Clonidine Benefits Children with ADD and Hyperactivity. Journal of the
American Academy of Child and Adolescent Psychiatry. 24:617-629.
Hynd, G., et al. Corpus Callosum Morphology in ADHD. Journal of Learning Disabilities. 24:
141-146.
Lubar, J., et al. Evaluation of EEG Neurofeedback Training for ADHD. Biofeedback and Self-
Regulation. 20:83-99.
McConnell, H. Catecholamine Metabolism in Attention Deficit Disorder: Implications for the
Use of Amino Acid Precursor Therapy. Medical Hypotheses. 1985; 17(4):305-311.
Nissen, S., M.D. ADHD Drugs and Cardiovascular Risk. The New England Journal of
Medicine. Apr. 6, 2006.
Pelham, W., et al. Sustained Release and Standard Methylphenidate Effects on Cognitive
and Social Behavior in Children with ADD. Pediatrics. 80:491-501.
Pliska, S. Tricyclic Antidepressants in the Treatment of Children with an ADHD Disorder.
Journal of the American Academy of Child and Adolescent Psychiatry. 26:127-133.
Spencer, T., et al. ADHD and Thyroid Abnormalities: A Research Note. Journal of Child
Psychology. 1995.
Stanley, J. A., Ph.D. In Vivo P Spectroscopy Evidence of Altered Membrane Phospholipid
Metabolites in Children with Attention-Deficit/Hyperactive Disorder. WPIC Research Day.
Jan. 18, 2006; 12.
Weinberg, W., et al. The Myth of the Attention Deficit Hyperactivity Disorder: Symptoms
Resulting from Multiple Causes. Journal of Child Neurology. 7(4):431-445.
Zametkin, A., et al. Cerebral Glucose Metabolism in Adults with Hyperactivity of Childhood
Onset. New England Journal of Medicine. 323(20):1351-1366.
Asthma Studies and Articles
Ballard, R. D. Nocturnal Asthma: Potential Mechanisms and Current Therapy. Clinical
Pulmonary Medicine. 1(5):271-278.
Bener, A., et al. Genetics and Environmental Risk Factors Associated with Asthma in
Schoolchildren. Allerg Immunol (Paris). May 2005; 37(5):163-168.
Britton, J. I., et al. Dietary Magnesium, Lung Function, Wheezing, and Airway Hyper-
reactivity in a Random Adult Population Sample. Lancet. 344:357-362.
Check, W. A., et al. Pharmacology and Pharmokinetics of Topical Corticosteroid
Derivatives Used for Asthma Therapy. American Review of Respiratory Disease. 141:S44-
S51.
Cohet, C., et al. Infections, Medication Use, and the Prevalence of Symptoms of Asthma,
Rhinitis, and Eczema in Childhood. Journal of Epidemiology and Community Health. Oct.
2004; 59(10); 852-857.
Erbas, B., et al. Air Pollution and Childhood Asthma Emergency Hospital Admissions:
Estimating Intra-City Regional Variations. Int J Environ Health Res. Feb. 2005; 15(1):11-20.
Hurwitz, E. L., et al. Effects of Diphtheria-Tetanus-Pertussis or Tetanus Vaccination on
Allergies and Allergy-Related Respiratory Symptoms Among Children and Adolescents in
the US. Journal of Manipulative and Physiological Therapeutics. 2000: 318(7192):1173-
1176.
Kemp, T., et al. Is Infant Immunization a Risk Factor for Childhood Asthma or Allergy?
Epidemiology. 1997; 8:678.
Kikuchi, Y., et al. Chemosensitivity and Perception of Dyspnea in Patients with a History of
Near-fatal Asthma. The New England Journal of Medicine. 330:1329-1334.
Magnesium and Bronchial Asthma. International Journal of Alternative and Complementary
Medicine. Feb. 1996; 14.
Mazzarella, G. Th-1/Th-2 Lymphocyte Polarization in Asthma. Allergy. 2000; 55(61):6-9.
Noverr, M.C., et al. Role of Antibiotics and Fungal Microbia in Driving Pulmonary Allergic
Responses. Infectious Immunology. Sep. 2004; 72(9):4996-5003.
Regular Bronchodilators Worsen Asthma Control. The Lancet. 1990; 336:1391.
Spector, S.L. Leukotriene Inhibitors and Antagonists in Asthma (Part 1). Annals of Allergy,
Asthma and Immunology. 1995; 463-496.
Triche, E. W., et al. Low-Level Ozone Exposure and Respiratory Symptoms in Infants.
Environ Health Perspect. Dec. 2005.
Varner, A.E., et al. Inflammation in Asthma: Why Is It So Important? Journal of Respiratory
Diseases. 1966; 17(7):605-616.
Allergy Studies and Articles
Atherton, D. Role of Diet in Treating Atopic Eczema – Elimination Diets Can Be Beneficial.
British Medical Journal. 297:1458-1460.
Bazar, K. A., et al. Obesity and ADHD May Represent Different Manifestations of a Common
Environmental Oversampling Syndrome: A model for Revealing Mechanistic Overlap
Among Cognitive, Metabolic, and Inflammatory Disorders. Medical Hypotheses. 2006;66:
263-269.
Colborn, T. A Case for Revisiting the Safety of Pesticides: A Closer Look at
Neurodevelopment. Environ Health Perspect. 2006; 114:10-17.
Dandona, P., et al. Inflammation: The Link between Insulin Resistance, Obesity and
Diabetes. Trends in Immunology. Jan. 2004; 25(1).
Del Prete, G. F., et al. Allergen Exposure Induces the Activation of Allergen-Specific Th-2
Cells in the Airway Mucosa of Patients with Allergic Respiratory Disorders. Eur J Immnol.
1993: 23:1445-1449.
El-Sherif, Y., et al. Melatonin Regulates Neuronal Plasticity in the Hippocampus. J
Neurosci Res. 2003; 72(4):454-460.
Esposito, K., et al. Inflammatory Cytokines Concentrations are Acutely Increased by
Hyperglycemia in Humans: Role of Oxidative Stress. Circulation. 2002; 106:2067-2072.
Gregus, Z., et al. Effect of Lipoic Acid on Biliary Excretion of Glutathione and Metals.
Toxicology & Applied Pharmacology. May 1992; 114(1):88-96.
Grosse, S. D., et al. Economic Gains Resulting from the Reduction in Children’s Exposure
to Lead in the United States. Environmental Health Perspectives. Jun. 2002; 110(4): 563-
369.
Hagberg, H., et al. Effect of Inflammation on Central Nervous System Development and
Vulnerability. Current Opinion in Neurology. 2005; 18:117-123.
Hattevig, G., et al. Clinical Symptoms and IgE Responses to Common Food Proteins and
Inhalants in the First 7 Years of Life. Clin Allergy. 1987; 17:571-578.
Lourdes, S., et al. Reduced Intellectual Development in Children with Prenatal Lead
Exposure. Environmental Health News. 2005.
Milburn, L. J., et al. Corticosteroids Restore the Balance between Locally Produced Th-1
and Th-2 Cytokines and Immunoglobulin Isotypes to Normal in Sarcoid Lung. Clin Exp
Immunol. 1997; 188:105-113.
Mosman, T. R., et al. The Expanding Universe of T-Cell Subsets. Th-1, Th-2 and More.
Immunol Today. 1996; 17:138-146.
Nori. M., et al. Ebastine Inhibits T-Cell Migration, Production of Th-2-Type Cytokines and
Proinflammatory Cytokines. Clin Exp Allergy. 2001; 33:1544.1554.
Ohta, N. Analysis of Th-1, Th-2, Tc-1 and Tc-2 Cells in Patients with Allergic Rhinitis. Clin
Exp All Rev. 2005; 5:68-71.
Padgett, D. A., et al. How Stress Influences the Immune Response. Trends Immunol. 2003;
24:444-448.
Perry, V. H. The Influence of Systemic Inflammation on Inflammation in the Brain:
Implications for Chronic Neurodegenerative Disease. Brain Behav Immun. 2004; 18:407-
413.
Pradhan, A.D., et al. C-Reactive Protein, Interleukin 6, and Risk of Developing Type-2
Diabetes Mellitus. JAMA. 2001;286:327-334.
Ross, R. Atherosclerosis – An Inflammatory Disease. N Engl J Med. 1999; 340:115-126.
Royal, F. F., M.D. Food Allergy Addiction in a Bariatric Practice. Obesity and Bariatric
Medicine. (1978; 7:45).
Sahashi, K., et al. Significance of Interleukin 6 in Patients with Sarcoidosis. Chest. 1994;
106:156-160.
Spalter, A. R., et al. Thyroid Function in Bulimia Nervosa. Biological Psychiatry. Mar. 15,
1993; 408-414.
Stannegard, O. Early Sensitization to Food Antigens – When and How? Pediatric Allergy
and Immunology. 2001; Suppl 14:20-23.
Weiner, H. L. Oral Tolerance: Immune Mechanisms and Treatment of Autoimmune
Diseases. Immunol Today. 1997; 18:335-341.
Wucherpfennig, K. W. Mechanisms for the Induction of Autoimmunity by Infectious Agents.
J Clin Invest. 2001; 108:1097-1104.
Xu, H., et al. Chronic Inflammation in Fat Plays a Crucial Role in the Development of
Obesity-Related Insulin Resistance. The Journal of Clinical Investigation. Dec. 2003; III(12)
